And I respond... so??? It looks pretty compelling to me, especially
when combined with many other such non-drug company funded studies that
show similar results. Your attempt to denigrate the study with unproven
suppositions of subclinical disease and influenced by a survivor bias
just don't cut the mustard with me. This study states: "The hazard
ratios of dying for subjects in the second, third, and fourth quartiles
compared with the first quartile of TC were computed using Cox
proportional hazards, adjusting for lifestyle factors, anthropomorphic
and biochemical measures, preexisting medical conditions, and frailty
indicators."
In other words, they have done their best to remove the biases you
purport (with no supporting data) to have not been removed.
Back to regularly scheduled programming.
Dr. Hi Cholesterol (and happy about it)
On 12/9/2010 12:53 PM, usher99@xxxxxxx wrote:
> CONCLUSION: Subjects with low TC levels (<189 mg/dL) are at higher risk
> of dying even when many related factors have been taken into account.
> Although more data are needed to clarify the association between TC and
> all-cause mortality in older individuals, physicians may want to regard
> very low levels of cholesterol as potential warning signs of occult
> disease or as signals of rapidly declining health.
>
> PMID: 12834520 [PubMed - indexed for MEDLINE]
>
>
>> From Chuck's link--
> So??? This is not compelling data and is misleading if meant to imply
> that high chol is a good thing. . People with subclinical disease
> (read occult malignancy) often eat poorly and have low total
> cholesterol concentrations thus a lower chol when following chol in an
> observational fashion may vary inversely with mortality. High LDL is
> definitely not a good thing for those with known coronary disease.
> There is also a survivor's bias---those that ate many big macs and were
> at risk of atherogenic vascular disease had long since turned to dust.
> A junk food diet clogs porcine arteries faster than almost anything
> else.
>
> Endocrinologist, clinical researcher not eating a big Mac if a gun is
> put to my head, Mike
--
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