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Re: [OM] IMG: Nathan's PAW 52: on two wheels and on two legs in and arou

Subject: Re: [OM] IMG: Nathan's PAW 52: on two wheels and on two legs in and around Alicante,
From: Mike Gordon via olympus <olympus@xxxxxxxxxxxxxxxxx>
Date: Thu, 17 Dec 2015 20:16:09 -0500
Cc: usher99@xxxxxxx
>      BTW:  The cat in the first two is actually a she, as all calicos are 
> female, or so I am told.

AG writes:

Hmm... I didn't think that was necessarily true, but sufficient to say, rare.


Well, to be a bit more precise all are female or are phenotypic males with an 
abnormal sex chromosome complement---usually XXY or Klinefelter's syndrome.  I 
certainly have a substantial number of such patients
but none are currently cats.  Recently diagnosed one patient at age 60.  None 
to pleased, but did appreciate being repeleted with testosterone.  I don't know 
 why the random inactivation of X chromosomes in female placental mammals is 
deemed  a "hypothesis", though it was so in 1961.
Not all the genes are silenced either---those homologous to  the Y chromo are 
often still active.   

Former long time denizen of molecular biology lab,  Mike
-- 
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